WVU MEDICINE
The West Virginia University Rockefeller Neuroscience Institute (RNI) launched a
first-in-the-world clinical trial pairing focused ultrasound treatment with Alzheimer’s antibody drug therapy to a targeted area of the brain, unlocking new potential for the treatment of the disease.
The first participant, a 77-year-old man from West Virginia, received the combination of Aduhelm (generic: aducanumab), a monoclonal antibody treatment that targets beta amyloid plaques as part of the FDA-approved trial.
With the antibody in the patient’s bloodstream, researchers aimed ultrasound waves to specific brain regions with beta amyloid to temporarily open the blood-brain barrier to facilitate drug delivery. The procedure was the first of a series of treatments the patient will undergo over six months.
While Aduhelm was FDA approved for the treatment of Alzheimer’s last year, its effects may be limited by ability to cross the protective blood-brain barrier. By opening this barrier and allowing the drug to enter the brain in key areas where amyloid plaques are present, researchers hope to potentially accelerate the plaque-clearing process while also delivering smaller doses of the drug, limiting potential side effects.
In 2018, the RNI became the first in the U.S. to use focused ultrasound to treat a patient with early-stage Alzheimer’s disease. The RNI team has since expanded treatment to multiple brain locations in that ongoing clinical trial, sponsored by INSIGHTEC. The team’s peer-reviewed studies have been published in the Proceedings of the National Academy of Sciences, Frontiers in Human Neuroscience and Radiology.
“After years of successfully using focused ultrasound to safely and locally open the blood-brain barrier, we’ve now taken a critical step forward in pairing this capability with therapeutic treatment,” Dr. Ali Rezai, executive chair of the WVU Rockefeller Neuroscience Institute, said. “We thank our patient and his family for being pioneers for this first-in-the-world study, which we hope leads to long-overdue relief for those struggling with Alzheimer’s.”
The RNI team partnered with INSIGHTEC, which developed the technology and manufactures the focused ultrasound device, Exablate Neuro.
The WVU Rockefeller Neuroscience Institute improves lives by pioneering advances in brain health and therapeutics. With the latest technologies, innovative research, an ecosystem of partners and a multidisciplinary integrated approach to patient care, the RNI is making tangible progress in its goal to combat public health challenges ranging from addiction to Alzheimer’s. For more information about the WVU Rockefeller Neuroscience Institute, visit WVUMedicine.org/RNI.
